Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.50 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.49 |
| ▸ | CCR2 | P41597 | 8/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459450 | 0.88 | ENPP1 (0.47) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL2457283 | 0.86 | ENPP1 (0.46) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL2465378 | 0.86 | ALKBH3 (0.41) | ENPP1ALKBH3CCR2NR3C1 | |
| SCHEMBL2458532 | 0.85 | ENPP1 (0.45) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL2461260 | 0.85 | CCR2 (0.48) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL2462543 | 0.85 | ENPP1 (0.45) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL12858718 | 0.85 | KDM4E (0.48) | ENPP1ALKBH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL2457593 | 0.84 | ENPP1 (0.43) | ENPP1ALKBH3CCR2PDE1BCCR5 | |
| SCHEMBL2462884 | 0.84 | ENPP1 (0.44) | ENPP1ALKBH3CCR2PDE1BPDE3B | |
| SCHEMBL2429495 | 0.83 | ENPP1 (0.43) | ENPP1ALKBH3CCR2PDE1BCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |