Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16960777 | 0.76 | IMPDH2 (0.37) | RAD51CA1CA2VCAM1ENPP2 | |
| SCHEMBL6901018 | 0.76 | RAD51 (0.43) | RAD51CA1CA2GABRPGABRD | |
| SCHEMBL5613280 | 0.76 | RAD51 (0.40) | RAD51CA1CA2PIN1IMPDH2 | |
| SCHEMBL30355307 | 0.76 | RAD51 (0.43) | RAD51CA1CA2GABRPGABRD | |
| SCHEMBL7195384 | 0.76 | RAD51 (0.40) | RAD51CA1CA2GABRPGABRD | |
| SCHEMBL16959161 | 0.76 | CYP2A6 (0.44) | RAD51CA1CA2MEN1KMT2A | |
| SCHEMBL23835197 | 0.74 | RAD51 (0.39) | RAD51PIN1MEN1KMT2AIMPDH2 | |
| SCHEMBL16959683 | 0.74 | MEN1 (0.38) | RAD51CA2MEN1KMT2AIMPDH2 | |
| SCHEMBL2693856 | 0.74 | KIF11 (0.36) | RAD51CA2IMPDH2IMPDH1CYP2A6 | |
| SCHEMBL16953034 | 0.74 | CYP2A6 (0.41) | RAD51CA2TDP1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051316-B2 | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-09 | — | — | US | disclosed |
| US-9051316-B2 | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-09 | — | — | US | disclosed |
| US-9051316-B2 | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-09 | — | — | US | disclosed |
| EP-2132206-B1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER IP GMBH (DE) | 2015-04-01 | — | — | EP | disclosed |
| EP-2132206-B1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER IP GMBH (DE) | 2015-04-01 | — | — | EP | disclosed |
| US-20140100243-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE AMIDES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-10 | — | — | US | disclosed |
| US-8436180-B2 | Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-8436180-B2 | Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-8436180-B2 | Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-8404709-B2 | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20100136142-A1 | SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER SCHERING PAHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| US-20100136142-A1 | SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER SCHERING PAHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| EP-2132206-A2 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | Bayer Schering Pharma AG (DE) | 2009-12-16 | — | — | EP | disclosed |
| EP-2029591-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008104306-A2 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008104306-A2 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2007140934-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007140934-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0807621-A1 | Derivatives of phenylglycine and use thereof as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140100243-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE AMIDES AND THEIR USE | NAT1, AADAC, QDPR | RAD51 3807/4885CA1 4826/4885CA2 3852/4885 |
| US-20100136142-A1 | SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF | NAT1, AADAC, QDPR | RAD51 3519/4885CA1 4800/4885CA2 3864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.