Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577782 | 0.84 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL24579168 | 0.83 | KIT (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL24576968 | 0.79 | BRD4 (0.41) | PTGS1PTGS2 | |
| SCHEMBL24579164 | 0.77 | KIT (0.39) | KITKDM5BFGFR1FGFR2FGFR3 | |
| SCHEMBL24579034 | 0.77 | KIT (0.35) | KITKDM5BKDR | |
| SCHEMBL24577992 | 0.74 | IKBKE (0.42) | KDM5BABL1 | |
| SCHEMBL24578202 | 0.73 | CDC7 (0.35) | PTGS1PTGS2ABL1KDR | |
| SCHEMBL24578249 | 0.72 | KDM4E (0.43) | KITABL1 | |
| SCHEMBL24577338 | 0.69 | HDAC6 (0.39) | KIT | |
| SCHEMBL24578329 | 0.68 | MAPT (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |