Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576990 | 0.90 | IKBKE (0.41) | IKBKETBK1BACE1KDM5BKAT5 | |
| SCHEMBL24577471 | 0.82 | BACE1 (0.40) | IKBKETBK1BACE1KDM5BKAT5 | |
| SCHEMBL24578874 | 0.81 | IKBKE (0.40) | IKBKETBK1BACE1KDM5BPRKAA1 | |
| SCHEMBL24576968 | 0.80 | BRD4 (0.41) | IKBKETBK1USP30FLT3 | |
| SCHEMBL24577482 | 0.79 | IKBKE (0.43) | IKBKETBK1BACE1CSF1RKAT5 | |
| SCHEMBL24578823 | 0.79 | IKBKE (0.48) | IKBKETBK1BACE1KAT5USP30 | |
| SCHEMBL29759699 | 0.79 | IKBKE (0.48) | IKBKETBK1BACE1KAT5USP30 | |
| Hydrochloric Acid SCHEMBL29759717 | 0.78 | IKBKE (0.47) | IKBKETBK1BACE1KAT5USP30 | |
| SCHEMBL29760255 | 0.78 | IKBKE (0.44) | IKBKETBK1BACE1PRKAA1PRKAB2 | |
| SCHEMBL24576905 | 0.76 | NR3C1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |