Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.34 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576968 | 0.78 | BRD4 (0.41) | MKNK1MKNK2FYNIKBKETBK1 | |
| SCHEMBL24578202 | 0.77 | CDC7 (0.35) | ABL1 | |
| SCHEMBL24577218 | 0.76 | JAK2 (0.37) | KDM4EALDH1A1GAACYP3A4PIK3CA | |
| SCHEMBL24577782 | 0.74 | PTGS1 (0.33) | — | |
| SCHEMBL24578258 | 0.73 | HTT (0.33) | ALDH1A1GAACYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL24578329 | 0.72 | MAPT (0.30) | — | |
| SCHEMBL24577563 | 0.72 | KIT (0.40) | KITABL1 | |
| SCHEMBL24578161 | 0.71 | RAB9A (0.36) | KDM4EALDH1A1GAAMKNK1MKNK2 | |
| SCHEMBL24577992 | 0.71 | IKBKE (0.42) | IKBKETBK1FEN1ABL1 | |
| SCHEMBL29760263 | 0.70 | CDC7 (0.43) | MKNK2DYRK3MAP4K4CDK9STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |