Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759558 | 1.00 | HDAC2 (0.32) | HDAC2HDAC1NR3C1P2RY12CHRM1 | |
| SCHEMBL24577065 | 0.87 | IKBKE (0.37) | HDAC2HDAC1CHRM1PDGFRAHRH3 | |
| SCHEMBL29759924 | 0.87 | IKBKE (0.37) | HDAC2HDAC1CHRM1PDGFRAHRH3 | |
| SCHEMBL29759921 | 0.86 | NR3C1 (0.34) | NR3C1 | |
| SCHEMBL24577986 | 0.86 | NR3C1 (0.34) | NR3C1 | |
| SCHEMBL24577658 | 0.86 | NR3C1 (0.31) | NR3C1 | |
| SCHEMBL29759860 | 0.86 | NR3C1 (0.31) | NR3C1 | |
| SCHEMBL29759866 | 0.85 | IKBKE (0.36) | HDAC2HDAC1CHRM1PDGFRAHRH3 | |
| SCHEMBL24578771 | 0.84 | PDGFRA (0.40) | HDAC1CHRM1PDGFRAHRH3 | |
| SCHEMBL29759700 | 0.84 | PDGFRA (0.40) | HDAC1CHRM1PDGFRAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |