Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | WNT1 | P04628 | 3/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579106 | 0.88 | RAB9A (0.34) | GSK3BDYRK1AWNT1ALDH1A1KDM4E | |
| SCHEMBL24577551 | 0.88 | GSK3B (0.44) | GSK3BDYRK1AWNT1ITGA4ITGB7 | |
| SCHEMBL24578957 | 0.87 | RAB9A (0.34) | GSK3BDYRK1AWNT1ALDH1A1KDM4E | |
| SCHEMBL24577452 | 0.85 | WNT1 (0.36) | GSK3BDYRK1AWNT1ITGA4ITGB7 | |
| SCHEMBL24577847 | 0.85 | IRAK4 (0.33) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL24579051 | 0.85 | IRAK4 (0.31) | ALDH1A1MEN1KMT2A | |
| SCHEMBL24577394 | 0.85 | POLB (0.33) | POLB | |
| SCHEMBL24577267 | 0.83 | WNT1 (0.33) | GSK3BDYRK1AWNT1POLB | |
| SCHEMBL24579060 | 0.83 | KDM1A (0.31) | — | |
| SCHEMBL24577557 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |