Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 5/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759982 | 0.82 | WNT1 (0.39) | WNT1GSK3BDYRK1AWNT3A | |
| SCHEMBL24577325 | 0.82 | WNT1 (0.39) | WNT1GSK3BDYRK1AMAPK8 | |
| SCHEMBL24576978 | 0.80 | GSK3B (0.41) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577786 | 0.79 | IKBKE (0.34) | — | |
| SCHEMBL24577632 | 0.79 | GSK3B (0.41) | WNT1GSK3BDYRK1AWNT3A | |
| SCHEMBL24579124 | 0.78 | WNT1 (0.33) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577046 | 0.78 | GSK3B (0.46) | WNT1GSK3BDYRK1A | |
| SCHEMBL24578720 | 0.78 | WNT1 (0.38) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577394 | 0.77 | POLB (0.33) | MAPK8 | |
| SCHEMBL24577050 | 0.77 | GSK3B (0.38) | WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |