Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23989466 | 0.78 | HTR2C (0.46) | HTR2CDRD2DRD1DRD4DRD5 | |
| SCHEMBL25556441 | 0.78 | MGLL (0.42) | ALOX15ALOX12MGLLHDAC4MAPT | |
| SCHEMBL1515269 | 0.77 | HTR2C (0.74) | HTR2CDRD2DRD1DRD4DRD5 | |
| SCHEMBL25359116 | 0.77 | SLC6A3 (0.46) | HTR2CHTR2ASLC6A4HTR2BSLC6A3 | |
| SCHEMBL30531032 | 0.76 | SLC6A3 (0.45) | HTR2CHTR2ASLC6A4HTR2BSLC6A3 | |
| SCHEMBL25465635 | 0.75 | MAOB (0.47) | HTR2CHTR2AHTR2BALOX15ALOX12 | |
| SCHEMBL1085761 | 0.74 | MAOB (0.43) | MAPT | |
| SCHEMBL14893808 | 0.74 | HTR2C (0.58) | HTR2CDRD2DRD3HTR2AHTR2B | |
| SCHEMBL26013444 | 0.74 | HTR1A (0.35) | HTR2CDRD2DRD1DRD4DRD5 | |
| SCHEMBL2538410 | 0.74 | HTR2C (0.69) | HTR2CDRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140169-A1 | PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-06-30 | — | — | WO | disclosed |