Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | KDM5C | P41229 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.32 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715022 | 0.84 | HDAC6 (0.38) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL27776751 | 0.84 | HDAC6 (0.41) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL27844192 | 0.82 | HDAC6 (0.41) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL27603813 | 0.81 | HDAC6 (0.41) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL23541555 | 0.77 | HDAC6 (0.38) | HDAC6HDAC1HDAC2 | |
| SCHEMBL631111 | 0.76 | EGLN1 (0.48) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL247895 | 0.76 | KDM6B (0.37) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL20136953 | 0.75 | PHF8 (0.42) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| Chloromethane SCHEMBL3415691 | 0.74 | EGLN1 (0.46) | PHF8KDM2AEGLN1KDM6BKDM5C | |
| SCHEMBL28595621 | 0.74 | PHF8 (0.45) | PHF8KDM2AEGLN1KDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512158-B2 | Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes | NEWLINK GENETICS CORPORATION (US) | 2016-12-06 | — | — | US | disclosed |
| EP-2089051-B1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NEWLINK GENETICS (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9090643-B2 | Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes | NEWLINK GENETICS CORPORATION (US) | 2015-07-28 | — | — | US | disclosed |
| US-8916169-B2 | Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes | NEWLINK GENETICS CORPORATION (US) | 2014-12-23 | — | — | US | disclosed |
| US-20130178613-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NewLink Genetics Corp. (US) | 2013-07-11 | — | — | US | disclosed |
| US-20130164319-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NewLink Genetics Corp. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130164318-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NewLink Genetics Corp. (US) | 2013-06-27 | — | — | US | disclosed |
| US-8357777-B2 | Enhanced immunogenicity of tumor associated antigens by addition of αgal epitopes | NEWLINK GENETICS (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120003251-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NEWLINK GENETICS (US) | 2012-01-05 | — | — | US | disclosed |
| US-7998486-B2 | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes | NEWLINK GENETICS CORPORATION (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2089051-A2 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | Newlink Genetics (US) | 2009-08-19 | — | — | EP | disclosed |
| US-20090060930-A1 | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes | NEWLINK GENETICS | 2009-03-05 | — | — | US | disclosed |
| WO-2008057235-A9 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NEWLINK GENETICS (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008057235-A2 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | NEWLINK GENETICS (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164319-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | ENGASE, FUT5, FUT6 | PHF8 4215/4885KDM2A 3774/4885EGLN1 3735/4885 |
| US-20130178613-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | ENGASE, FUT5, FUT6 | PHF8 4215/4885KDM2A 3774/4885EGLN1 3735/4885 |
| US-20090060930-A1 | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes | ENGASE, FUT5, FUT6 | PHF8 4215/4885KDM2A 3774/4885EGLN1 3735/4885 |
| US-20120003251-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | ENGASE, GALE, FUT5 | PHF8 4182/4885KDM2A 2691/4885EGLN1 3084/4885 |
| US-20130164318-A1 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES | ENGASE, FUT5, FUT6 | PHF8 4215/4885KDM2A 3774/4885EGLN1 3735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.