SCHEMBL24593196

SCHEMBL24593196

C[Si](C)(C)Oc1ccc(Cc2cc(Br)ccc2Cl)cc1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.43
SLC6A4 P31645 2/20 0.43
KCNH2 Q12809 2/20 0.43
SLC5A2 P31639 16/20 0.39
SLC5A1 P13866 9/20 0.39
ADRA2A P08913 1/20 0.37
SLC5A11 Q8WWX8 1/20 0.37
MEN1 O00255 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL181184 0.87 HTR2A (0.40) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL30263682 0.83 SLC5A2 (0.50) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL181109 0.83 SLC5A2 (0.50) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL29386304 0.81 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL38150 0.81 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL2870097 0.80 SLC6A4 (0.37) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL19303580 0.79 HTR2A (0.43) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL3683414 0.79 SLC5A2 (0.51) HTR2ASLC6A4KCNH2SLC5A2SLC5A1
SCHEMBL14938792 0.79 SLC5A2 (0.52) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL38651021 0.79 L3MBTL1 (0.44) HTR2ASLC6A4KCNH2SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4023644-A1 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT Zaklady Farmaceutyczne Polpharma SA (PL) 2022-07-06 EP disclosed