Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 4/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 11/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539254 | 0.81 | SLC5A2 (0.47) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL37715 | 0.81 | SLC5A2 (0.47) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL12782162 | 0.81 | CCR5 (0.47) | SLC6A4HTR2AKCNH2CCR5 | |
| SCHEMBL24593196 | 0.80 | HTR2A (0.43) | SLC6A4HTR2AKCNH2SLC5A2SLC5A1 | |
| SCHEMBL500031 | 0.80 | SLC6A4 (0.37) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL1539252 | 0.79 | SLC5A2 (0.49) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL17842 | 0.78 | MEN1 (0.46) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL29816996 | 0.78 | MEN1 (0.46) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL1457579 | 0.78 | APP (0.40) | SLC6A4HTR2AKCNH2CCR5SLC5A2 | |
| SCHEMBL499287 | 0.78 | SLC5A2 (0.38) | SLC6A4HTR2AKCNH2CCR5SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851602-B2 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7851602-B2 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7772378-B2 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772378-B2 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1910390-B1 | GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)CYCLOALYKLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER (SGLT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2010-05-19 | — | — | EP | disclosed |
| EP-1856082-B1 | GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)ARYLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1910390-A2 | GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)CYCLOALYKLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER (SGLT) INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| EP-1856082-A1 | GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)ARYLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2007014894-A2 | GLUCOPYRANOSYL-SUBSTITUTED ( (HETERO) CYCLOALYKLETHYNYL-BENZYL) -BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER (SGLT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027092-A1 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-01 | — | — | US | disclosed |
| US-20070027092-A1 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-01 | — | — | US | disclosed |
| WO-2006089872-A1 | GLUCOPYRANOSYL-SUBSTITUTED ( (HETERO)ARYLETHYNYL-BENZYD-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-08-31 | — | — | WO | disclosed |
| US-20060189548-A1 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027092-A1 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | UGGT1, GPR119, UGT2B7 | SLC6A4 1553/4885HTR2A 1806/4885KCNH2 1006/4885 |
| US-20060189548-A1 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture | UGGT1, UGT2B7, GPR119 | SLC6A4 1076/4885HTR2A 1233/4885KCNH2 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.