Sugi Predict

Sugi Predict / Compounds / SCHEMBL2459920

SCHEMBL2459920

SCHEMBL2459920

COC(=O)C1CC(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)C1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.38
▸ JAK2 O60674 1/20 0.37
▸ JAK1 P23458 1/20 0.37
▸ ADAM17 P78536 2/20 0.36
▸ HDAC4 P56524 1/20 0.36
▸ MRGPRX4 Q96LA9 1/20 0.35
▸ F10 P00742 1/20 0.35
▸ MAOB P27338 1/20 0.35
▸ FAAH O00519 3/20 0.35
▸ S1PR1 P21453 1/20 0.35
▸ PRKX P51817 1/20 0.35
▸ ACVR1 Q04771 1/20 0.35
▸ S1PR5 Q9H228 1/20 0.35
▸ NR1H4 Q96RI1 1/20 0.35
▸ CNR2 P34972 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ ERN1 O75460 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460497 0.93 JAK2 (0.40) IGF1RJAK2JAK1HDAC4MRGPRX4
SCHEMBL2463346 0.87 IGF1R (0.35) IGF1RJAK2JAK1HDAC4MRGPRX4
SCHEMBL2459738 0.87 MAOB (0.37) IGF1RJAK2JAK1ADAM17HDAC4
SCHEMBL2460369 0.86 IGF1R (0.38) IGF1RMRGPRX4
SCHEMBL6014584 0.85 SLC6A2 (0.39) IGF1RJAK2JAK1ADAM17HDAC4
SCHEMBL2459426 0.85 BRD4 (0.36) JAK2JAK1HDAC4MRGPRX4MAOB
SCHEMBL2460301 0.84 IGF1R (0.35) IGF1RJAK2JAK1MAOBERN1
SCHEMBL2465897 0.83 F9 (0.34) IGF1RADAM17MRGPRX4F10MAOB
SCHEMBL2458133 0.83 IGF1R (0.41) IGF1RJAK2JAK1HDAC4F10
SCHEMBL2460207 0.83 NR1H2 (0.35) IGF1RJAK2JAK1HDAC4MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885JAK2 9/4885JAK1 23/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885JAK2 9/4885JAK1 23/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885JAK2 9/4885JAK1 23/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.