Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463346

SCHEMBL2463346

SCHEMBL2463346

OC1CC(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)C1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 7/20 0.35
▸ TNK2 Q07912 1/20 0.35
▸ NR1H2 P55055 1/20 0.35
▸ PDE10A Q9Y233 1/20 0.35
▸ MRGPRX4 Q96LA9 1/20 0.35
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ F9 P00740 1/20 0.34
▸ F10 P00742 1/20 0.34
▸ HDAC4 P56524 1/20 0.34
▸ NAAA Q02083 1/20 0.34
▸ CA2 P00918 1/20 0.33
▸ CA5A P35218 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ JAK1 P23458 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460369 0.91 IGF1R (0.38) IGF1RTNK2NR1H2PDE10AMRGPRX4
SCHEMBL2460636 0.89 IGF1R (0.39) IGF1RTNK2PDE10AMRGPRX4CYP4F2
SCHEMBL2459426 0.88 BRD4 (0.36) NR1H2PDE10AMRGPRX4HDAC4JAK2
SCHEMBL2460207 0.88 NR1H2 (0.35) IGF1RTNK2NR1H2PDE10AMRGPRX4
SCHEMBL2459738 0.87 MAOB (0.37) IGF1RMRGPRX4HDAC4JAK2JAK1
SCHEMBL2459920 0.87 IGF1R (0.38) IGF1RMRGPRX4F10HDAC4JAK2
SCHEMBL2465897 0.87 F9 (0.34) IGF1RTNK2NR1H2PDE10AMRGPRX4
SCHEMBL2459990 0.87 IGF1R (0.39) IGF1RTNK2NR1H2PDE10ACYP4F2
SCHEMBL2464664 0.86 CYP4F2 (0.34) IGF1RTNK2NR1H2PDE10AMRGPRX4
SCHEMBL2463487 0.86 PRMT5 (0.38) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885TNK2 760/4885NR1H2 2603/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885TNK2 760/4885NR1H2 2603/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885TNK2 760/4885NR1H2 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.