Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24624620 | 0.75 | CDK2 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22758634 | 0.75 | NR1I2 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18948474 | 0.75 | NR1I2 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13535383 | 0.68 | ALDH1A1 (0.38) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5712462 | 0.67 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8370472 | 0.64 | NR1I2 (0.41) | LMNA | |
| SCHEMBL25488041 | 0.64 | HCAR2 (0.44) | ALDH1A1 | |
| SCHEMBL18948422 | 0.64 | HCAR2 (0.44) | ALDH1A1 | |
| SCHEMBL21946582 | 0.63 | NR1I2 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24608829 | 0.62 | GPR84 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227446-A9 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2023-07-20 | — | — | US | disclosed |
| US-20220213096-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NANJING ZHENGXIANG PHARMACEUTICALS CO LTD (CN) | 2022-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227446-A9 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PI4KB, PI4KA, PIK3CD | PSEN1 3482/4885PSEN2 3211/4885APH1B 1613/4885 |
| US-20220213096-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PI4KB, PI4KA, PIK3CD | PSEN1 3482/4885PSEN2 3211/4885APH1B 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.