Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460034

SCHEMBL2460034

SCHEMBL2460034

CCOc1ccc(C2=NC(C3=CC=C3)=C3C=NC=C[N+]23Cl)cc1OCc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.37
▸ LMNA P02545 3/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ ATM Q13315 1/20 0.36
▸ MRGPRX4 Q96LA9 1/20 0.35
▸ MAPT P10636 4/20 0.34
▸ POLB P06746 1/20 0.34
▸ THRB P10828 1/20 0.34
▸ HSD17B10 Q99714 3/20 0.34
▸ MAPK1 P28482 2/20 0.33
▸ NTSR1 P30989 2/20 0.33
▸ GAA P10253 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ HTR1A P08908 2/20 0.33
▸ ADRA1D P25100 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2465932 0.92 PDE4A (0.39) KDM4ELMNAALDH1A1MRGPRX4MAPT
SCHEMBL2461788 0.90 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
SCHEMBL2460708 0.88 KDM4E (0.35) KDM4ELMNAALDH1A1MEN1KMT2A
SCHEMBL2461373 0.88 MRGPRX4 (0.32) MRGPRX4PTGER1
SCHEMBL2460481 0.80 PDE4A (0.39) KDM4ELMNAALDH1A1MAPTHSD17B10
SCHEMBL2460343 0.78 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
SCHEMBL2457091 0.78 MRGPRX4 (0.33) LMNAMRGPRX4MAPTMAPK1L3MBTL1
SCHEMBL2459494 0.77 KDR (0.35) —
SCHEMBL2463035 0.71 BCHE (0.37) MRGPRX4
SCHEMBL2465962 0.68 NR1H2 (0.42) LMNAMEN1KMT2AMRGPRX4THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 KDM4E 1461/4885LMNA 3821/4885ALDH1A1 703/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 KDM4E 1461/4885LMNA 3821/4885ALDH1A1 703/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 KDM4E 1461/4885LMNA 3821/4885ALDH1A1 703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.