Sugi Predict

Sugi Predict / Compounds / SCHEMBL2465962

SCHEMBL2465962

SCHEMBL2465962

COC(=O)c1ccc(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ MRGPRX4 Q96LA9 2/20 0.39
▸ SMPD1 P17405 2/20 0.39
▸ MAOB P27338 1/20 0.39
▸ SPHK2 Q9NRA0 2/20 0.38
▸ LMNA P02545 2/20 0.38
▸ HPGD P15428 1/20 0.38
▸ NR1H4 Q96RI1 1/20 0.38
▸ NR4A2 P43354 2/20 0.38
▸ HDAC4 P56524 1/20 0.37
▸ ESR1 P03372 1/20 0.37
▸ THRA P10827 1/20 0.37
▸ THRB P10828 1/20 0.37
▸ VDR P11473 1/20 0.37
▸ RXRA P19793 1/20 0.37
▸ PPARG P37231 1/20 0.37
▸ PPARD Q03181 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2462309 0.93 MRGPRX4 (0.43) NR1H2MEN1KMT2AMRGPRX4SMPD1
SCHEMBL2456978 0.89 MRGPRX4 (0.40) NR1H2SMN1; SMN2MRGPRX4MAOBLMNA
SCHEMBL2461277 0.84 ALOX5 (0.40) NR1H2MRGPRX4HDAC4ALOX5
SCHEMBL2459986 0.83 TSHR (0.39) NR1H2SMN1; SMN2MRGPRX4MAOBLMNA
SCHEMBL2458350 0.81 MRGPRX4 (0.38) NR1H2SMN1; SMN2MRGPRX4MAOBLMNA
SCHEMBL2460199 0.80 PARP10 (0.45) MRGPRX4SMPD1MAOBSPHK2NR4A2
SCHEMBL3537188 0.80 JAK2 (0.45) MEN1KMT2AMRGPRX4MAOBNR4A2
SCHEMBL2460381 0.79 MAOB (0.38) NR1H2MRGPRX4MAOBNR4A2
SCHEMBL2463359 0.79 NR1H2 (0.39) NR1H2MRGPRX4ALOX5
SCHEMBL3540151 0.78 BCHE (0.38) NR1H2KMT2AMRGPRX4MAOBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 NR1H2 2603/4885MEN1 1004/4885KMT2A 1100/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 NR1H2 2603/4885MEN1 1004/4885KMT2A 1100/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 NR1H2 2603/4885MEN1 1004/4885KMT2A 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.