Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 9/20 | 0.36 |
| ▸ | KIT | P10721 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808733 | 0.78 | PTGS2 (0.38) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL2808729 | 0.78 | PTGS2 (0.38) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL2806973 | 0.78 | PTGS2 (0.44) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL185826 | 0.75 | PTGS2 (0.41) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL186734 | 0.74 | PTGS2 (0.41) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL13159905 | 0.69 | HTR1A (0.42) | PTGS2FLT3 | |
| SCHEMBL2784614 | 0.69 | JAK1 (0.43) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL27870363 | 0.68 | PTGS2 (0.42) | PTGS2JAK1JAK3FLT3KIT | |
| SCHEMBL2809973 | 0.66 | PTGS2 (0.37) | PTGS2JAK1JAK3JAK2 | |
| SCHEMBL2809975 | 0.66 | PTGS2 (0.37) | PTGS2JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |