Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185826 | 0.84 | PTGS2 (0.41) | PTGS2JAK1JAK3JAK2EPHX2 | |
| SCHEMBL14957673 | 0.81 | ALDH1A1 (0.41) | EPHX2MEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27870381 | 0.79 | PTGS2 (0.38) | PTGS2JAK1JAK3JAK2EPHX2 | |
| SCHEMBL14957374 | 0.77 | CNR2 (0.36) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL27870364 | 0.76 | PTGS2 (0.37) | PTGS2JAK1JAK3JAK2EPHX2 | |
| SCHEMBL2784614 | 0.75 | JAK1 (0.43) | PTGS2JAK1JAK3JAK2EPHX2 | |
| SCHEMBL246040 | 0.74 | PTGS2 (0.41) | PTGS2JAK1JAK3JAK2TYK2 | |
| SCHEMBL2806973 | 0.74 | PTGS2 (0.44) | PTGS2JAK1JAK3JAK2EPHX2 | |
| SCHEMBL186039 | 0.73 | CHEK1 (0.50) | CHEK1 | |
| SCHEMBL185856 | 0.72 | RAB9A (0.40) | MEN1CYP1A2CYP2D6CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |