Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460423

SCHEMBL2460423

SCHEMBL2460423

N[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ NR4A2 P43354 2/20 0.41
▸ MAOB P27338 9/20 0.40
▸ NR1H2 P55055 1/20 0.40
▸ NR1H3 Q13133 1/20 0.40
▸ MRGPRX4 Q96LA9 1/20 0.39
▸ MAOA P21397 2/20 0.37
▸ MAPT P10636 2/20 0.36
▸ POLB P06746 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ IDO1 P14902 2/20 0.35
▸ FFAR1 O14842 1/20 0.34
▸ FFAR4 Q5NUL3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460057 0.90 MAOB (0.35) MAOBMRGPRX4
SCHEMBL2459633 0.89 MAOB (0.39) NR4A2MAOBMRGPRX4MAOA
SCHEMBL2460200 0.89 MAOB (0.37) NR4A2MAOBNR1H2MRGPRX4
SCHEMBL2456898 0.88 NOS1 (0.35) NR4A2MAOBMRGPRX4
SCHEMBL2458288 0.88 IDO1 (0.34) NR1H2IDO1
SCHEMBL2461743 0.87 NR4A2 (0.39) NR4A2MAOBMAOA
SCHEMBL2460724 0.87 MRGPRX4 (0.34) NR4A2MRGPRX4
SCHEMBL2458187 0.87 MAOB (0.39) MAOBMRGPRX4MAOAIDO1FFAR1
SCHEMBL2463293 0.87 MAOB (0.42) MAOBMRGPRX4MAOA
SCHEMBL2458043 0.86 IGF1R (0.37) NR4A2MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 NR4A2 1075/4885MAOB 1546/4885NR1H2 2603/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 NR4A2 1075/4885MAOB 1546/4885NR1H2 2603/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 NR4A2 1075/4885MAOB 1546/4885NR1H2 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.