Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463293

SCHEMBL2463293

SCHEMBL2463293

N[N+]12C=CN=CC1=C(C1=CC=C1)N=C2c1cccc(OCc2cccc(Br)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 14/20 0.42
▸ MAOA P21397 7/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.36
▸ NPC1 O15118 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ PARP15 Q460N3 3/20 0.34
▸ PARP10 Q53GL7 3/20 0.34
▸ PARP14 Q460N5 1/20 0.34
▸ TNKS2 Q9H2K2 1/20 0.33
▸ PARP2 Q9UGN5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460200 0.91 MAOB (0.37) MAOBMRGPRX4
SCHEMBL2456898 0.90 NOS1 (0.35) MAOBMRGPRX4
SCHEMBL2461743 0.89 NR4A2 (0.39) MAOBMAOA
SCHEMBL2460724 0.89 MRGPRX4 (0.34) MRGPRX4SMN1; SMN2
SCHEMBL2459633 0.89 MAOB (0.39) MAOBMAOAMRGPRX4PARP10
SCHEMBL2458187 0.89 MAOB (0.39) MAOBMAOAMRGPRX4NPC1RAB9A
SCHEMBL2461522 0.88 ALOX5 (0.34) MAOBMAOAMRGPRX4
SCHEMBL2460741 0.87 SMPD1 (0.36) MAOBMRGPRX4
SCHEMBL2460057 0.87 MAOB (0.35) MAOBMRGPRX4
SCHEMBL2459648 0.87 MRGPRX4 (0.50) MRGPRX4RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 MAOB 1546/4885MAOA 1799/4885MRGPRX4 1767/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 MAOB 1546/4885MAOA 1799/4885MRGPRX4 1767/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 MAOB 1546/4885MAOA 1799/4885MRGPRX4 1767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.