Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24607224 | 0.99 | EPHX2 (0.43) | EPHX2LMNAALDH1A1KMT2AFAAH | |
| SCHEMBL25466978 | 0.91 | FAAH (0.42) | LMNAALDH1A1KMT2AFAAHTSHR | |
| SCHEMBL23945202 | 0.91 | FAAH (0.42) | LMNAALDH1A1KMT2AFAAHTSHR | |
| SCHEMBL25591306 | 0.90 | ALDH1A1 (0.42) | LMNAALDH1A1KMT2AFAAHTSHR | |
| SCHEMBL25467143 | 0.88 | EPHX2 (0.39) | EPHX2LMNAALDH1A1KMT2AFAAH | |
| SCHEMBL24508250 | 0.86 | KDM4E (0.47) | EPHX2LMNAALDH1A1KMT2AFAAH | |
| SCHEMBL22906477 | 0.86 | FAAH (0.53) | EPHX2KMT2AFAAHTSHRRECQL | |
| SCHEMBL22790739 | 0.86 | FAAH (0.53) | EPHX2KMT2AFAAHTSHRRECQL | |
| SCHEMBL22790646 | 0.86 | KDM4E (0.47) | EPHX2LMNAALDH1A1KMT2AFAAH | |
| SCHEMBL23559960 | 0.86 | KMT2A (0.50) | EPHX2LMNAALDH1A1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081759-A1 | BIFUNCTIONAL PI3K-ALPHA INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |