Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SI | P14410 | 3/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555909 | 0.77 | ALDH5A1 (0.43) | ALDH1A1TDP1ERN1HSD17B10HPGD | |
| SCHEMBL27851500 | 0.77 | TDP1 (0.50) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL1287837 | 0.76 | ALDH1A1 (0.74) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL30535903 | 0.76 | ALDH1A1 (0.74) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL9696347 | 0.76 | PRKDC (0.41) | ALDH1A1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL30987815 | 0.74 | ALDH1A1 (0.71) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL29337140 | 0.74 | ALDH1A1 (0.71) | ALDH1A1TDP1MGAMGAASI | |
| Ammonia Solution, Strong SCHEMBL9060371 | 0.74 | ALDH1A1 (0.71) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL6210201 | 0.74 | ERN1 (0.58) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL2463968 | 0.73 | ESR2 (0.59) | ALDH1A1TDP1MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464646-B1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | PELLICCIARI ROBERTO (IT) | 2009-09-30 | — | — | EP | claimed |
| EP-1464646-A1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | SMITHKLINE BEECHAM PLC (GB) | 2004-10-06 | — | — | EP | claimed |
| US-20040082789-A1 | Thieno[2,3-c]iosquinolines for use as inhibitors of parp | MORONI, FLAVIO (IT) | 2004-04-29 | — | — | US | claimed |
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PELLICCIARI ROBERTO | 2011-09-29 | — | — | US | disclosed |
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PELLICCIARI ROBERTO | 2011-09-29 | — | — | US | disclosed |
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PELLICCIARI ROBERTO | 2011-09-29 | — | — | US | disclosed |
| US-7825129-B2 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2010-11-02 | — | — | US | disclosed |
| US-7825129-B2 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2010-11-02 | — | — | US | disclosed |
| US-7825129-B2 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2010-11-02 | — | — | US | disclosed |
| EP-1464646-B1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | PELLICCIARI ROBERTO (IT) | 2009-09-30 | — | — | EP | disclosed |
| US-20060094746-A1 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PELLICCIARI ROBERTO | 2006-05-04 | — | — | US | disclosed |
| US-6989388-B2 | Thieno[2,3-c]iosquinolines for use as inhibitors of PARP | Pellicciari, Roberto (IT) | 2006-01-24 | — | — | US | disclosed |
| EP-1464646-A1 | Thieno(2,3-C) Isoquinolines for use as inhibitors of Parp | SMITHKLINE BEECHAM PLC (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040082789-A1 | Thieno[2,3-c]iosquinolines for use as inhibitors of parp | MORONI, FLAVIO (IT) | 2004-04-29 | — | — | US | disclosed |
| EP-1332147-A1 | THIENO[2,3-C ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | SMITHKLINE BEECHAM PLC (GB) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002036599-A1 | THIENO[2,3-C]ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237617-A1 | THIENO[2,3-C] ISOQUINOLINES FOR USE AS INHIBITORS OF PARP | PARP1, PARP2, PARP3 | ALDH1A1 136/4885TDP1 42/4885MGAM 4211/4885 |
| US-20040082789-A1 | Thieno[2,3-c]iosquinolines for use as inhibitors of parp | PARP1, PARP2, PARP12 | ALDH1A1 1365/4885TDP1 53/4885MGAM 4090/4885 |
| US-20060094746-A1 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP | PARP1, PARP2, PARP3 | ALDH1A1 136/4885TDP1 42/4885MGAM 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.