Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21427579 | 0.79 | MAPT (0.37) | POLBALDH1A1GAAMAPTHTT | |
| SCHEMBL19152022 | 0.76 | EPHX2 (0.35) | KMT2APOLBALDH1A1GAAMAPT | |
| SCHEMBL20244530 | 0.76 | MDM4 (0.35) | — | |
| SCHEMBL12694226 | 0.73 | ALDH1A1 (0.40) | KMT2APOLBALDH1A1GAAMAPT | |
| SCHEMBL24060363 | 0.73 | ALDH1A1 (0.38) | KMT2AALDH1A1MAPTHTTMEN1 | |
| SCHEMBL12782076 | 0.71 | NFKB1 (0.46) | KMT2APKMPOLBALDH1A1GAA | |
| SCHEMBL12196007 | 0.71 | NFKB1 (0.46) | KMT2APKMPOLBALDH1A1GAA | |
| SCHEMBL12693335 | 0.68 | HNF4A (0.36) | KMT2AALDH1A1HTTMEN1SMN1; SMN2 | |
| SCHEMBL27551091 | 0.66 | ALDH1A1 (0.48) | KMT2APKMPOLBALDH1A1GAA | |
| SCHEMBL27630001 | 0.66 | ALDH1A1 (0.48) | KMT2APOLBALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347355-B1 | HETEROTRICYCLIC SULFONAMIDES AS ANTI-CANCER AGENTS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2022-07-13 | — | — | EP | disclosed |