Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SNCA | P37840 | 1/20 | 0.64 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.64 |
| ▸ | NQO2 | P16083 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3679372 | 0.92 | KMT2A (0.76) | MAPTKDM4ETDP1KMT2AMEN1 | |
| SCHEMBL21798720 | 0.92 | KMT2A (0.76) | MAPTKDM4ETDP1KMT2AMEN1 | |
| SCHEMBL899585 | 0.90 | DEGS1 (0.75) | KDM4EGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL900928 | 0.90 | DEGS1 (0.75) | KDM4EGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8420639 | 0.90 | DEGS1 (0.75) | KDM4EGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL674688 | 0.86 | HDAC6 (0.69) | MAPTKMT2AMEN1TP53USP2 | |
| SCHEMBL16583981 | 0.85 | KMT2A (0.74) | MAPTKDM4EKMT2AMEN1TP53 | |
| SCHEMBL16592202 | 0.85 | KMT2A (0.74) | MAPTKDM4EKMT2AMEN1TP53 | |
| SCHEMBL20284045 | 0.84 | DEGS1 (0.86) | KDM4ESMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL8770541 | 0.84 | DEGS1 (0.68) | MAPTKDM4ETDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035777-B | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO | 2013-01-02 | — | — | CN | disclosed |
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | disclosed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | disclosed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | disclosed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | disclosed |
| CN-101035777-A | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-09-12 | — | — | CN | disclosed |
| EP-1799663-A1 | MODULATORS OF HCV REPLICATION | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038039-A1 | MODULATORS OF HCV REPLICATION | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069344-A1 | Modulators of hcv replication | EIF2AK2, IRF3, IFNAR1 | MAPT 4662/4885KDM4E 2063/4885ALDH1A1 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.