Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615410 | 0.88 | TYK2 (0.45) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615414 | 0.87 | JAK1 (0.42) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615408 | 0.86 | TYK2 (0.42) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL29772862 | 0.85 | JAK1 (0.44) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615407 | 0.85 | TYK2 (0.46) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615583 | 0.85 | JAK1 (0.44) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615295 | 0.84 | JAK2 (0.40) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615433 | 0.83 | JAK2 (0.49) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615298 | 0.81 | JAK2 (0.40) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615235 | 0.80 | TYK2 (0.44) | TYK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |