Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.41 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 4/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615424 | 0.89 | TYK2 (0.41) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615367 | 0.89 | TYK2 (0.42) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615600 | 0.88 | JAK1 (0.40) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL29772862 | 0.88 | JAK1 (0.44) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615583 | 0.88 | JAK1 (0.44) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615601 | 0.87 | TYK2 (0.41) | TYK2JAK2JAK1JAK3SMARCA2 | |
| SCHEMBL24615598 | 0.87 | JAK1 (0.42) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615368 | 0.85 | TYK2 (0.41) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL29772821 | 0.85 | JAK1 (0.40) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615433 | 0.81 | JAK2 (0.49) | TYK2JAK2JAK1JAK3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |