Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.42 |
| ▸ | JAK2 | O60674 | 15/20 | 0.42 |
| ▸ | JAK1 | P23458 | 15/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615471 | 0.89 | JAK1 (0.39) | TYK2JAK2JAK1JAK3IRAK4 | |
| SCHEMBL24615488 | 0.85 | JAK2 (0.40) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29772733 | 0.82 | JAK1 (0.42) | JAK1FFAR1 | |
| SCHEMBL24615235 | 0.82 | TYK2 (0.44) | TYK2JAK2JAK1JAK3KDR | |
| SCHEMBL24615373 | 0.81 | TYK2 (0.44) | TYK2JAK2JAK1JAK3KDR | |
| SCHEMBL29772744 | 0.80 | JAK1 (0.41) | TYK2JAK2JAK1JAK3KDR | |
| SCHEMBL29772730 | 0.80 | JAK1 (0.41) | TYK2JAK2JAK1JAK3KDR | |
| SCHEMBL24615433 | 0.80 | JAK2 (0.49) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL24615410 | 0.78 | TYK2 (0.45) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL24615448 | 0.77 | JAK1 (0.41) | TYK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274832-A1 | TYK2 INHIBITORS | Biogen MA Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |