Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24371127 | 0.81 | HTR4 (0.42) | NR1I2HSD11B1NPC1RAB9AALDH1A1 | |
| SCHEMBL27017623 | 0.80 | HTR4 (0.35) | NR1I2HSD11B1NPC1RAB9AALDH1A1 | |
| SCHEMBL21348795 | 0.77 | SMN1; SMN2 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24615934 | 0.72 | NPC1 (0.35) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26701981 | 0.69 | NPC1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2605414 | 0.69 | NUDT1 (0.41) | NR1I2HSD11B1HPGDTSHRPIK3CG | |
| SCHEMBL11031081 | 0.69 | USP7 (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21348767 | 0.68 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6269053 | 0.68 | NR1I2 (0.40) | NR1I2HSD11B1KDM4EHSD17B10HPGD | |
| SCHEMBL24368132 | 0.68 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148422-A1 | BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2022-07-14 | — | — | WO | disclosed |