Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.57 |
| ▸ | TACR3 | P29371 | 13/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372855 | 0.85 | DHODH (0.71) | DHODHPDE10ATSHR | |
| SCHEMBL3959255 | 0.84 | TACR3 (0.68) | DHODHTACR3CYP3A4PDE10ATSHR | |
| SCHEMBL28984340 | 0.83 | TRPV4 (0.60) | TACR3CYP3A4TACR2 | |
| SCHEMBL2373011 | 0.81 | DHODH (0.58) | DHODHTACR3PDE10ATSHR | |
| SCHEMBL2372279 | 0.81 | DHODH (0.50) | DHODHTACR3PDE10ATSHRTACR2 | |
| SCHEMBL30389983 | 0.80 | ADORA2A (0.43) | DHODHTACR3TACR2LMNARORB | |
| SCHEMBL5171551 | 0.80 | TACR3 (0.70) | TACR3CYP3A4 | |
| SCHEMBL5172525 | 0.80 | TACR3 (0.60) | TACR3CYP3A4 | |
| SCHEMBL4906015 | 0.79 | TACR3 (0.79) | TACR3CYP3A4 | |
| SCHEMBL2372559 | 0.78 | TRPV4 (0.50) | DHODHTACR3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |