Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372559 | 0.88 | TRPV4 (0.50) | DHODHTRPV4TACR1TACR2TACR3 | |
| SCHEMBL2372767 | 0.88 | DHODH (0.56) | DHODH | |
| SCHEMBL5908769 | 0.87 | DHODH (0.57) | DHODHPDE10ALMNATACR1TSHR | |
| SCHEMBL5945355 | 0.87 | LMNA (0.54) | DHODHPDE10ALMNATSHRPOLB | |
| SCHEMBL2373864 | 0.87 | DHODH (0.54) | DHODHLMNA | |
| SCHEMBL5908732 | 0.86 | DHODH (0.67) | DHODH | |
| SCHEMBL1581252 | 0.84 | DHODH (0.65) | DHODHPDE10ALMNATSHRTACR2 | |
| SCHEMBL2372855 | 0.83 | DHODH (0.71) | DHODHPDE10ATSHR | |
| SCHEMBL2461670 | 0.81 | DHODH (0.57) | DHODHPDE10ALMNATSHRTACR2 | |
| SCHEMBL2373306 | 0.79 | DHODH (0.51) | DHODHTRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |