Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.35 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | DRD4 | P21917 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24616690 | 0.85 | ALDH1A1 (0.38) | HCAR2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL24616779 | 0.85 | HCAR2 (0.37) | CCR2HCAR2 | |
| SCHEMBL24616798 | 0.83 | HCAR2 (0.36) | HCAR2ALDH1A1 | |
| SCHEMBL24616758 | 0.82 | APP (0.37) | KMT2AMEN1ALDH1A1THRB | |
| SCHEMBL24616687 | 0.82 | CA1 (0.35) | HCAR2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL24616776 | 0.80 | ALDH1A1 (0.36) | HCAR2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL24616783 | 0.80 | KMT2A (0.48) | KMT2AALDH1A1THRB | |
| SCHEMBL24616741 | 0.79 | HCAR2 (0.32) | HCAR2 | |
| SCHEMBL24616696 | 0.79 | SLC6A2 (0.35) | CCR2HCAR2 | |
| SCHEMBL29395638 | 0.79 | SLC6A2 (0.35) | CCR2HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | claimed |
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |