Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.61 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779067 | 1.00 | ROCK2 (0.61) | ROCK2ROCK1TNIKLMNAHTT | |
| SCHEMBL1431418 | 0.87 | GAA (0.51) | ROCK2ROCK1TNIKHDAC3HDAC4 | |
| SCHEMBL5946784 | 0.83 | GRM5 (0.67) | LMNAGRM5 | |
| SCHEMBL29249887 | 0.82 | PKM (0.49) | ROCK2ROCK1TNIKLMNAHTT | |
| SCHEMBL30914663 | 0.82 | PKM (0.49) | ROCK2ROCK1TNIKLMNAHTT | |
| SCHEMBL29438690 | 0.82 | GRM5 (0.62) | ROCK2ROCK1TNIKGRM5DRD2 | |
| SCHEMBL4502402 | 0.82 | GRM5 (0.62) | ROCK2ROCK1TNIKGRM5DRD2 | |
| SCHEMBL28882904 | 0.81 | ROCK2 (0.71) | ROCK2ROCK1TNIK | |
| SCHEMBL3052820 | 0.80 | ROCK2 (0.55) | ROCK2ROCK1TNIKHDAC3HDAC4 | |
| SCHEMBL31414530 | 0.80 | HRH3 (0.53) | ROCK2ROCK1TNIKLMNAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |