Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29500293 | 0.86 | DRD3 (0.59) | HRH3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5946784 | 0.83 | GRM5 (0.67) | HRH3GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL24617036 | 0.80 | ROCK2 (0.61) | ROCK2ROCK1GRM5DRD3DRD2 | |
| SCHEMBL29779067 | 0.80 | ROCK2 (0.61) | ROCK2ROCK1GRM5DRD3DRD2 | |
| SCHEMBL6819309 | 0.79 | LMNA (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27049079 | 0.77 | NPBWR1 (0.44) | HRH3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29644814 | 0.76 | PRMT5 (0.45) | HRH3GRM5PRMT5WDR77 | |
| SCHEMBL16593829 | 0.75 | PTGER4 (0.58) | DRD3DRD2KCNH2PTGER4PTGER2 | |
| SCHEMBL582220 | 0.73 | GRM5 (0.51) | HRH3GRM5ALDH1A1GAAKMT2A | |
| SCHEMBL29926219 | 0.73 | GRM5 (0.55) | HRH3GRM5KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735422-A1 | SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF TREATING PHENYLKETONURIA AND OTHER AMINO ACIDURIAS | Sanofi (FR) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006827-A1 | SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF TREATING PHENYLKETONURIA AND OTHER AMINO ACIDURIAS | GENZYME CORPORATION (US) | 2025-01-02 | — | — | WO | disclosed |