Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.32 |
| ▸ | MICA | Q29983 | 1/20 | 0.32 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778584 | 1.00 | METAP2 (0.35) | METAP2ROCK2ROCK1TDO2BRAF | |
| SCHEMBL24616960 | 0.92 | METAP2 (0.35) | METAP2ROCK2ROCK1TDO2TAF1 | |
| SCHEMBL29778502 | 0.92 | METAP2 (0.35) | METAP2ROCK2ROCK1TDO2TAF1 | |
| SCHEMBL29778457 | 0.89 | METAP2 (0.36) | METAP2ROCK2ROCK1TAF1 | |
| SCHEMBL24617461 | 0.89 | METAP2 (0.36) | METAP2ROCK2ROCK1TAF1 | |
| SCHEMBL29135932 | 0.84 | TDO2 (0.40) | METAP2ROCK2ROCK1TDO2BRAF | |
| SCHEMBL29778614 | 0.84 | TDO2 (0.40) | METAP2ROCK2ROCK1TDO2BRAF | |
| SCHEMBL24616964 | 0.82 | TAF1 (0.35) | METAP2ROCK2ROCK1TDO2TAF1 | |
| SCHEMBL29778659 | 0.82 | TAF1 (0.35) | METAP2ROCK2ROCK1TDO2TAF1 | |
| SCHEMBL24617623 | 0.82 | WNT1 (0.37) | METAP2ROCK2ROCK1TDO2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |