Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.62 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.51 |
| ▸ | CLK1 | P49759 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857915 | 0.83 | CYP1A2 (0.51) | DYRK1ATBXAS1DYRK1BCLK1MAP2K1 | |
| SCHEMBL30298112 | 0.83 | TBXAS1 (0.54) | DYRK1ATBXAS1BCL2L1DYRK1BCNR1 | |
| SCHEMBL15395548 | 0.83 | PLOD2 (0.60) | DYRK1ATBXAS1BCL2L1DYRK1BMAP2K1 | |
| SCHEMBL8338532 | 0.82 | DYRK1A (0.76) | DYRK1ABCL2L1DYRK1BCLK1CNR1 | |
| SCHEMBL24621241 | 0.81 | MAP2K1 (0.47) | DYRK1ATBXAS1MAP2K1HDAC1HDAC6 | |
| SCHEMBL13045530 | 0.81 | DYRK1A (0.73) | DYRK1ABCL2L1DYRK1BCLK1CNR1 | |
| SCHEMBL6321234 | 0.79 | BCL2L1 (0.74) | DYRK1ABCL2L1DYRK1BCLK1CNR1 | |
| SCHEMBL31356465 | 0.79 | BCL2L1 (0.74) | DYRK1ABCL2L1DYRK1BCLK1CNR1 | |
| SCHEMBL11648291 | 0.75 | DYRK1A (0.74) | DYRK1ABCL2L1DYRK1BCLK1CNR1 | |
| SCHEMBL28260363 | 0.75 | DYRK1A (0.69) | DYRK1ABCL2L1DYRK1BCLK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148459-A1 | CLASS OF NOVEL SMAD3 PROTEIN DEGRADERS AND APPLICATION THEREOF | 和径医药科技（上海）有限公司 | 2022-07-14 | — | — | WO | disclosed |