Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 11/20 | 0.61 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588776 | 0.86 | ENPP1 (0.53) | ENPP1MBOAT4GAAALDH1A1TSHR | |
| SCHEMBL6712952 | 0.83 | ENPP1 (0.57) | ENPP1MBOAT4GAAHPGDALDH1A1 | |
| SCHEMBL24129144 | 0.75 | MBOAT4 (0.51) | ENPP1MBOAT4ALDH1A1 | |
| SCHEMBL8126098 | 0.74 | EGLN2 (0.50) | ENPP1CYP1A2CYP3A4GAAHPGD | |
| SCHEMBL22968380 | 0.73 | MBOAT4 (0.71) | ENPP1MBOAT4 | |
| SCHEMBL2582203 | 0.73 | ENPP1 (0.51) | ENPP1MBOAT4GAAALDH1A1TSHR | |
| SCHEMBL5470044 | 0.72 | ALDH1A1 (0.49) | ENPP1CYP3A4ALDH1A1 | |
| SCHEMBL5324250 | 0.69 | MBOAT4 (0.40) | ENPP1MBOAT4CYP1A2GAAALDH1A1 | |
| SCHEMBL2459450 | 0.68 | ENPP1 (0.47) | ENPP1PDE1BCCR2 | |
| SCHEMBL2455657 | 0.67 | ENPP1 (0.50) | ENPP1PDE1BALDH1A1KMT2ACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |