Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL244529 | 0.99 | MEN1 (0.50) | MEN1KMT2AGAAHTTNCOA1 | |
| SCHEMBL2534485 | 0.84 | MEN1 (0.65) | MEN1KMT2AGAAHTTNCOA1 | |
| SCHEMBL1473951 | 0.84 | NPC1 (0.54) | MEN1KMT2AGAAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3248224 | 0.83 | MEN1 (0.64) | MEN1KMT2AGAAHTTNCOA1 | |
| Hydrochloric Acid SCHEMBL1471256 | 0.83 | NPC1 (0.53) | MEN1KMT2AGAAHTTSMN1; SMN2 | |
| SCHEMBL4089919 | 0.83 | RAB9A (0.50) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL244941 | 0.83 | PTPN11 (0.46) | GAASMN1; SMN2ALDH1A1RAB9AP2RX1 | |
| Hydrochloric Acid SCHEMBL247568 | 0.82 | PTPN11 (0.45) | GAASMN1; SMN2ALDH1A1RAB9AP2RX1 | |
| SCHEMBL4095632 | 0.82 | KMT2A (0.53) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4096059 | 0.82 | RAB9A (0.49) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046118-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | claimed |
| EP-2209783-B1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | ANIONA APS (DK) | 2016-03-16 | — | — | EP | disclosed |
| US-8343960-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2013-01-01 | — | — | US | disclosed |
| US-20120004215-A1 | N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-01-05 | — | — | US | disclosed |
| US-20110046118-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20100298307-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046118-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | CHRNA6, CHRNA5, CHRNA2 | MEN1 4586/4885KMT2A 3160/4885GAA 3081/4885 |
| US-20100298307-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | CHRNA6, CHRNA5, CHRNA2 | MEN1 4586/4885KMT2A 3160/4885GAA 3081/4885 |
| US-20120004215-A1 | N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | CHRNA5, CHRNA6, CHRNA10 | MEN1 4249/4885KMT2A 3560/4885GAA 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.