Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27850545 | 0.90 | MAPT (0.44) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL14971063 | 0.88 | MAPT (0.43) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL22642271 | 0.83 | MAPT (0.40) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL13901633 | 0.82 | MAPT (0.48) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL25703933 | 0.80 | MAPT (0.68) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL388339 | 0.80 | MAPT (0.68) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL388338 | 0.80 | MAPT (0.68) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL23771890 | 0.78 | MAPT (0.46) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL19558883 | 0.78 | MAPT (0.46) | ABCB1MAPTGAAMGAMSI | |
| SCHEMBL4693411 | 0.78 | MAPT (0.46) | ABCB1MAPTGAAMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377470-B1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES USEFUL FOR PREPARING 1,3,4-TRIAZINE DERIVATIVES | FMC CORP (US) | 2020-11-11 | — | — | EP | claimed |
| US-10294196-B2 | Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives | FMC CORP (US) | 2019-05-21 | — | — | US | claimed |
| US-20180334427-A1 | Process for the Synthesis of Intermediates Useful for Preparing 1,3,4-Triazine Derivatives | FMC CORP (US) | 2018-11-22 | — | — | US | claimed |
| EP-3377470-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES USEFUL FOR PREPARING 1,3,4-TRIAZINE DERIVATIVES | FMC Corporation (US) | 2018-09-26 | — | — | EP | claimed |
| EP-3377470-B1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES USEFUL FOR PREPARING 1,3,4-TRIAZINE DERIVATIVES | FMC CORP (US) | 2020-11-11 | — | — | EP | disclosed |
| CN-105198861-B | 6- acyl group -1,2,4- triazine -3,5- derovatives and herbicide | FMC公司 | 2019-11-22 | — | — | CN | disclosed |
| US-10294196-B2 | Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives | FMC CORP (US) | 2019-05-21 | — | — | US | disclosed |
| US-10294196-B2 | Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives | FMC CORP (US) | 2019-05-21 | — | — | US | disclosed |
| US-10294196-B2 | Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives | FMC CORP (US) | 2019-05-21 | — | — | US | disclosed |
| EP-3317267-B1 | PYRIDAZINONES AS HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-05-08 | — | — | EP | disclosed |
| US-20190047968-A1 | 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES | FMC CORP (US) | 2019-02-14 | — | — | US | disclosed |
| US-20180334427-A1 | Process for the Synthesis of Intermediates Useful for Preparing 1,3,4-Triazine Derivatives | FMC CORP (US) | 2018-11-22 | — | — | US | disclosed |
| WO-2009074827-A2 | COMBINATION COMPRISING A MEK INHIBITOR AND AN AURORA KINASE INHIBITOR 188 | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009050506-A2 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | WO | disclosed |
| US-20090099174-A1 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20080280957-A1 | Heterocyclic Inhibitors of Mek and Methods of Use Thereof | ARRAY BIOPHARMA, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| EP-1967516-A1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | Array Biopharma, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099174-A1 | COMBINATION 059 | MTOR, RICTOR, MAPK9 | ABCB1 496/4885MAPT 4324/4885GAA 1659/4885 |
| US-20080280957-A1 | Heterocyclic Inhibitors of Mek and Methods of Use Thereof | BRAF, NRAS, MAP3K1 | ABCB1 2595/4885MAPT 4461/4885GAA 2860/4885 |
| US-10294196-B2 | Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives | DAZAP1, TALDO1, GMDS | ABCB1 4437/4885MAPT 3377/4885GAA 1833/4885 |
| US-20190047968-A1 | 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES | DDT, AADAC, DAZAP1 | ABCB1 2984/4885MAPT 3711/4885GAA 657/4885 |
| US-20180334427-A1 | Process for the Synthesis of Intermediates Useful for Preparing 1,3,4-Triazine Derivatives | DHPS, CYP4Z1, NISCH | ABCB1 4082/4885MAPT 3178/4885GAA 2796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.