Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388339 | 1.00 | MAPT (0.68) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL25703933 | 1.00 | MAPT (0.68) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL13952033 | 0.84 | MAPT (0.50) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL246273 | 0.80 | ABCB1 (0.49) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL13901633 | 0.80 | MAPT (0.48) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL9523119 | 0.79 | MAPT (0.75) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL16619928 | 0.78 | MAPT (0.61) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL1805493 | 0.78 | MAPT (0.72) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL13373635 | 0.78 | MAPT (0.72) | MAPTALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL12386668 | 0.78 | MAPT (0.72) | MAPTALDH1A1LMNAHSD17B10GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239755-A1 | SUBSTITUTED PYRIDAZINONES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | BAYER AKTIENGESELLSCHAFT (DE) | 2024-07-18 | — | — | US | disclosed |
| EP-4330234-A1 | SUBSTITUTED PYRIDAZINONES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | Bayer Aktiengesellschaft (DE) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022229055-A1 | SUBSTITUTED PYRIDAZINONES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | BAYER AKTIENGESELLSCHAFT (DE) | 2022-11-03 | — | — | WO | disclosed |
| EP-3169668-B1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2019-09-04 | — | — | EP | disclosed |
| US-9944608-B2 | Herbicidal pyridazinone derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-17 | — | — | US | disclosed |
| US-20170166535-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-06-15 | — | — | US | disclosed |
| EP-3169668-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | Syngenta Participations AG (CH) | 2017-05-24 | — | — | EP | disclosed |
| WO-2016008816-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-01-21 | — | — | WO | disclosed |
| US-9096533-B2 | Pyridazinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-08-04 | — | — | US | disclosed |
| US-9096534-B2 | Pyridazinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-08-04 | — | — | US | disclosed |
| US-20090215834-A1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090209542-A1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090111696-A1 | Pyridazinone Compound and Use Thereof as herbicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-04-30 | — | — | US | disclosed |
| US-7517994-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20080280957-A1 | Heterocyclic Inhibitors of Mek and Methods of Use Thereof | ARRAY BIOPHARMA, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| EP-1967516-A1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | Array Biopharma, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20070112038-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-05-17 | — | — | US | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20050256123-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112038-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, MAPK9 | MAPT 4827/4885ALDH1A1 1723/4885LMNA 2182/4885 |
| US-20080280957-A1 | Heterocyclic Inhibitors of Mek and Methods of Use Thereof | BRAF, NRAS, MAP3K1 | MAPT 4461/4885ALDH1A1 2121/4885LMNA 2319/4885 |
| US-20240239755-A1 | SUBSTITUTED PYRIDAZINONES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | PNPO, WEE1, PDXK | MAPT 3170/4885ALDH1A1 428/4885LMNA 2689/4885 |
| US-20090215834-A1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | NRAS, BRAF, MAPK9 | MAPT 4856/4885ALDH1A1 1533/4885LMNA 2616/4885 |
| US-20170166535-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | HPD, DDT, PDXK | MAPT 3377/4885ALDH1A1 184/4885LMNA 2484/4885 |
| US-20050256123-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, MAPK9 | MAPT 4830/4885ALDH1A1 1992/4885LMNA 2092/4885 |
| US-20090209542-A1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | NRAS, BRAF, MAPK9 | MAPT 4854/4885ALDH1A1 1327/4885LMNA 2655/4885 |
| US-20090111696-A1 | Pyridazinone Compound and Use Thereof as herbicides | PDXK, DDT, PLPBP | MAPT 3414/4885ALDH1A1 171/4885LMNA 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.