SCHEMBL24628486

SCHEMBL24628486

O=C(NCc1cccc(Br)c1)c1ccc(-c2ccc(O)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 4/20 0.62
ROCK1 Q13464 4/20 0.62
EGFR P00533 3/20 0.59
ALOX5 P09917 1/20 0.57
LMNA P02545 2/20 0.55
HPGD P15428 1/20 0.54
SENP1 Q9P0U3 1/20 0.54
HDAC1 Q13547 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52
POLB P06746 1/20 0.52
PRKACA P17612 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3422647 0.85 ROCK2 (0.62) ROCK2ROCK1EGFRLMNAHPGD
SCHEMBL6185148 0.84 HDAC6 (0.65) ALOX5LMNAHPGDSENP1HDAC1
SCHEMBL254400 0.83 ROCK2 (0.62) ROCK2ROCK1EGFRPRKACAGSK3A
SCHEMBL24628975 0.83 ROCK2 (0.62) ROCK2ROCK1EGFRHDAC1PRKACA
SCHEMBL26816033 0.83 ROCK2 (0.62) ROCK2ROCK1EGFRHDAC1HDAC2
SCHEMBL26844281 0.82 NPC1 (0.53) ROCK2ROCK1EGFRHDAC1HDAC2
SCHEMBL24628436 0.81 ROCK2 (0.60) ROCK2ROCK1EGFRSENP1HDAC1
SCHEMBL24629269 0.80 ROCK2 (0.58) ROCK2ROCK1EGFRHDAC1HDAC2
SCHEMBL254918 0.80 ROCK2 (0.78) ROCK2ROCK1EGFRSENP1HDAC1
SCHEMBL4483467 0.78 MMP13 (0.59) ROCK2ROCK1EGFRHPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4276092-A1 COMPOUND LIBRARY CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-15 EP disclosed
WO-2022149617-A1 COMPOUND LIBRARY 中外製薬株式会社 2022-07-14 WO disclosed