Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 11/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | AHR | P35869 | 1/20 | 0.78 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.77 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.77 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.77 |
| ▸ | GRM5 | P41594 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422941 | 0.87 | CHRNB2 (1.00) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL2462961 | 0.84 | CHRNB2 (0.90) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL13415320 | 0.83 | NPC1 (0.76) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL2460914 | 0.81 | NPC1 (0.74) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5174314 | 0.81 | NPC1 (0.73) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL2455727 | 0.81 | RAB9A (1.00) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL2649031 | 0.79 | MAPT (0.64) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL12653007 | 0.79 | NPC1 (0.70) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL6452359 | 0.79 | NPC1 (0.67) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL7050345 | 0.78 | MAPT (0.66) | NPC1RAB9AMAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294856-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | DAHL BJARNE H (DK) | 2011-12-01 | — | — | US | claimed |
| EP-2255848-A2 | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer | NeuroSearch AS (DK) | 2010-12-01 | — | — | EP | claimed |
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2010-09-16 | — | — | US | claimed |
| US-20090312347-A1 | Novel oxadiazole derivatives and their medical use | SANIONA A/S (DK) | 2009-12-17 | — | — | US | claimed |
| EP-2083921-A2 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2009-08-05 | — | — | EP | claimed |
| WO-2008028903-A2 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2008-03-13 | — | — | WO | claimed |
| EP-1881979-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2008-01-30 | — | — | EP | claimed |
| WO-2006114400-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-11-02 | — | — | WO | claimed |
| US-20110294856-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | DAHL BJARNE H (DK) | 2011-12-01 | — | — | US | disclosed |
| US-8017631-B2 | Oxadiazole derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-09-13 | — | — | US | disclosed |
| EP-2255848-A2 | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer | NeuroSearch AS (DK) | 2010-12-01 | — | — | EP | disclosed |
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2010-09-16 | — | — | US | disclosed |
| US-20090312347-A1 | Novel oxadiazole derivatives and their medical use | SANIONA A/S (DK) | 2009-12-17 | — | — | US | disclosed |
| EP-2083921-A2 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008028903-A2 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2008-03-13 | — | — | WO | disclosed |
| EP-1881979-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006114400-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312347-A1 | Novel oxadiazole derivatives and their medical use | CHRNA3, CHRNA5, CHRNB3 | NPC1 4073/4885RAB9A 4260/4885MAPT 1077/4885 |
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | CHRNA10, CHRNA4, CHRNA5 | NPC1 3329/4885RAB9A 2472/4885MAPT 365/4885 |
| US-20110294856-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA5, CHRNB3 | NPC1 4073/4885RAB9A 4260/4885MAPT 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.