Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172852 | 0.84 | TP53 (0.39) | TP53TSHRCYP3A4HSD17B10HSD11B1 | |
| SCHEMBL17404393 | 0.82 | FFAR1 (0.42) | CYP3A4KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL1415606 | 0.82 | ACACB (0.39) | TP53TSHRCYP3A4HSD17B10LMNA | |
| SCHEMBL31326225 | 0.82 | ACACB (0.39) | TP53TSHRCYP3A4HSD17B10LMNA | |
| SCHEMBL16114956 | 0.81 | PYCR1 (0.34) | — | |
| SCHEMBL20536435 | 0.81 | HSD17B10 (0.43) | TSHRCYP3A4HSD17B10KDM4EMAPT | |
| SCHEMBL29172857 | 0.81 | CYP11B2 (0.35) | HSD11B1RAB9ANPC1CYP1A2CYP2C19 | |
| SCHEMBL15540611 | 0.81 | PTGDR2 (0.37) | IDO1 | |
| SCHEMBL15227219 | 0.81 | CYP3A4 (0.44) | TP53TSHRCYP3A4HSD17B10LMNA | |
| SCHEMBL31029000 | 0.81 | PTGDR2 (0.37) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | TP53 2441/4885TSHR 2362/4885CYP3A4 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.