Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460223 | 0.92 | ENPP1 (0.43) | DAOENPP1PDE1BCCR2 | |
| SCHEMBL2464959 | 0.79 | ENPP1 (0.31) | ENPP1 | |
| SCHEMBL2459450 | 0.79 | ENPP1 (0.47) | DAOENPP1PDE1BCCR2 | |
| SCHEMBL2457421 | 0.79 | ALKBH3 (0.36) | DAOPDE1BCCR2TDP1 | |
| SCHEMBL2455163 | 0.79 | ENPP1 (0.43) | DAOENPP1CCR2 | |
| SCHEMBL2460016 | 0.79 | CCR2 (0.36) | ENPP1CCR2TDP1 | |
| SCHEMBL2454685 | 0.78 | DAO (0.36) | DAOENPP1PDE1B | |
| SCHEMBL2462973 | 0.78 | CCR2 (0.39) | DAOPDE1BCCR2 | |
| SCHEMBL2462277 | 0.77 | ENPP1 (0.31) | ENPP1 | |
| SCHEMBL2455657 | 0.77 | ENPP1 (0.50) | DAOENPP1PDE1BCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |