Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460223 | 0.83 | ENPP1 (0.43) | ENPP1 | |
| SCHEMBL2460016 | 0.79 | CCR2 (0.36) | ENPP1MEN1HPGDKMT2A | |
| SCHEMBL2455163 | 0.79 | ENPP1 (0.43) | ENPP1HPGD | |
| SCHEMBL2462976 | 0.77 | DAO (0.40) | ENPP1 | |
| SCHEMBL2459403 | 0.76 | TSHR (0.33) | ENPP1 | |
| SCHEMBL2456947 | 0.74 | DAO (0.33) | ENPP1MEN1KMT2A | |
| SCHEMBL2456758 | 0.74 | KDM4A (0.38) | — | |
| SCHEMBL2457055 | 0.71 | AR (0.35) | — | |
| SCHEMBL2455233 | 0.71 | DAO (0.38) | — | |
| SCHEMBL2459450 | 0.68 | ENPP1 (0.47) | ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |