Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29814077 | 0.88 | TEAD1 (0.42) | TEAD1YAP1SCN9ATNNI3KMEN1 | |
| SCHEMBL24631107 | 0.88 | TEAD1 (0.42) | TEAD1YAP1SCN9ATNNI3KMEN1 | |
| SCHEMBL27170923 | 0.85 | TEAD1 (0.42) | TEAD1YAP1SCN9AMEN1LMNA | |
| SCHEMBL24631244 | 0.85 | BRD4 (0.40) | TEAD1YAP1SCN9ATNNI3KLMNA | |
| SCHEMBL30868581 | 0.84 | BRD4 (0.41) | TEAD1YAP1L3MBTL1MEN1LMNA | |
| SCHEMBL27170897 | 0.84 | BRD4 (0.41) | TEAD1YAP1L3MBTL1MEN1LMNA | |
| SCHEMBL24879863 | 0.82 | TEAD1 (0.51) | TEAD1YAP1TNNI3KMAPT | |
| SCHEMBL24631206 | 0.82 | WDR5 (0.40) | TEAD1YAP1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL30114160 | 0.80 | TEAD1 (0.50) | TEAD1YAP1TNNI3KMAPT | |
| SCHEMBL24879883 | 0.80 | TEAD1 (0.50) | TEAD1YAP1TNNI3KMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
| EP-4294382-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | Merck Sharp & Dohme LLC (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022177869-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2022-08-25 | — | — | WO | disclosed |
| WO-2022177869-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2022-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | TEAD1 4/4885YAP1 176/4885SCN9A 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.