Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 3/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462190 | 0.82 | MAPK1 (0.67) | MAPTMAPK1L3MBTL1SYKLMNA | |
| SCHEMBL18286152 | 0.81 | MAPT (0.59) | MAPTMAPK1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL14910392 | 0.77 | SYK (0.54) | MAPTMAPK1L3MBTL1SYKCFTR | |
| SCHEMBL12336309 | 0.76 | MAPT (0.47) | MAPTMAPK1SYKLMNAALDH1A1 | |
| SCHEMBL25392363 | 0.74 | LMNA (0.76) | MAPTMAPK1L3MBTL1SYKLMNA | |
| SCHEMBL12501138 | 0.71 | MAPK1 (0.59) | MAPTMAPK1L3MBTL1SYKLMNA | |
| SCHEMBL2088462 | 0.71 | CFTR (0.53) | MAPTCFTRALDH1A1PKMGPR35 | |
| SCHEMBL29910288 | 0.71 | CFTR (0.53) | MAPTCFTRALDH1A1PKMGPR35 | |
| SCHEMBL6799074 | 0.71 | LMNA (0.66) | MAPTSYKLMNAPOLBALDH1A1 | |
| SCHEMBL9271694 | 0.70 | RXFP1 (0.70) | MAPTLMNAALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011116176-A1 | 3-SUBSTITUED IMIDAZO (4, 5-B) PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS INC. (US) | 2011-09-22 | — | — | WO | disclosed |