Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 8/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | IDH2 | P48735 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18286208 | 0.85 | AURKA (0.60) | MAPTAURKALMNAIDH2L3MBTL1 | |
| SCHEMBL2463141 | 0.81 | MAPT (0.52) | MAPTMAPK1LMNAIDH2L3MBTL1 | |
| SCHEMBL2462190 | 0.79 | MAPK1 (0.67) | MAPTMAPK1LMNAL3MBTL1AKR1C3 | |
| SCHEMBL3493237 | 0.78 | PHGDH (0.58) | MAPTAURKAMAPK1L3MBTL1THRB | |
| SCHEMBL18286170 | 0.76 | AURKA (0.58) | MAPTAURKALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL21960124 | 0.75 | MAPT (0.64) | MAPTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7528425 | 0.74 | MAPT (1.00) | MAPTMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL9271694 | 0.74 | RXFP1 (0.70) | MAPTLMNASMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL11367980 | 0.73 | AKR1C3 (0.56) | MAPTMAPK1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL25392363 | 0.72 | LMNA (0.76) | MAPTMAPK1LMNAL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10758522-B2 | Small molecule analogs of the nemo binding peptide | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180169078-A1 | Small Molecule Analogs of the Nemo Binding Peptide | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2018-06-21 | — | — | US | disclosed |
| EP-3302468-A1 | SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE | The Scripps Research Institute (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196117-A1 | SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10758522-B2 | Small molecule analogs of the nemo binding peptide | IKBKG, NFKBIA, NFKB1 | MAPT 932/4885AURKA 1864/4885MAPK1 546/4885 |
| US-20180169078-A1 | Small Molecule Analogs of the Nemo Binding Peptide | IKBKG, NFKBIA, NFKB1 | MAPT 932/4885AURKA 1864/4885MAPK1 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.