Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088462 | 1.00 | CFTR (0.53) | CFTRNOTUMMAPTGABRPGABRD | |
| SCHEMBL21044587 | 0.88 | NOTUM (0.53) | CFTRNOTUMMAPTSMN1; SMN2KDM4E | |
| SCHEMBL16303300 | 0.82 | NOTUM (0.47) | CFTRNOTUMMAPTGABRPGABRD | |
| SCHEMBL30261881 | 0.81 | NOTUM (0.46) | CFTRNOTUMMAPTGABRPGABRD | |
| SCHEMBL16505957 | 0.81 | NOTUM (0.46) | CFTRNOTUMMAPTGABRPGABRD | |
| SCHEMBL21044459 | 0.79 | NOTUM (0.47) | CFTRNOTUMMAPTSMN1; SMN2KDM4E | |
| SCHEMBL23326908 | 0.77 | ADORA3 (0.49) | CFTRNOTUMMAPTKDM4EGPR35 | |
| SCHEMBL20943981 | 0.77 | NOTUM (0.47) | CFTRNOTUMMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30745008 | 0.77 | NOTUM (0.47) | CFTRNOTUMMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29910346 | 0.77 | ADORA3 (0.49) | CFTRNOTUMMAPTKDM4EGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055017-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |