Sugi Predict

Sugi Predict / Compounds / SCHEMBL2463359

SCHEMBL2463359

SCHEMBL2463359

Cl[N+]12C=CN=CC1=C(c1cccc3ccccc13)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 2/20 0.39
▸ BACE1 P56817 1/20 0.38
▸ P2RY14 Q15391 1/20 0.36
▸ F9 P00740 1/20 0.36
▸ F10 P00742 1/20 0.36
▸ MAPT P10636 2/20 0.35
▸ MRGPRX4 Q96LA9 1/20 0.35
▸ DHODH Q02127 3/20 0.35
▸ ALOX5 P09917 1/20 0.34
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34
▸ PRKDC P78527 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2456978 0.89 MRGPRX4 (0.40) NR1H2BACE1F9F10MRGPRX4
SCHEMBL2465920 0.88 BACE1 (0.39) NR1H2BACE1P2RY14F9F10
SCHEMBL2461277 0.87 ALOX5 (0.40) NR1H2BACE1F9F10MRGPRX4
SCHEMBL2459986 0.84 TSHR (0.39) NR1H2BACE1MAPTMRGPRX4CYP4F2
SCHEMBL2458350 0.83 MRGPRX4 (0.38) NR1H2BACE1MRGPRX4DHODHCYP4F2
SCHEMBL2460371 0.81 NR1H2 (0.42) NR1H2BACE1MRGPRX4CYP4F2CYP4A11
SCHEMBL2460621 0.80 NR1H2 (0.39) NR1H2MRGPRX4DHODHCYP4F2CYP4A11
SCHEMBL2460381 0.80 MAOB (0.38) NR1H2MRGPRX4CYP4F2CYP4A11
SCHEMBL3538747 0.79 MAOB (0.38) NR1H2BACE1F9F10MRGPRX4
SCHEMBL3540151 0.79 BCHE (0.38) NR1H2BACE1MRGPRX4CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 NR1H2 2603/4885BACE1 3130/4885P2RY14 3097/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 NR1H2 2603/4885BACE1 3130/4885P2RY14 3097/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 NR1H2 2603/4885BACE1 3130/4885P2RY14 3097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.